Acetaldehyde → 2-Ethylcyclohexane-1,3-dione

HRID 1519401Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1519401
[C:1]1(=[O:8])[CH2:6][CH2:5][CH2:4][C:3](=[O:7])[CH2:2]1.[CH3:9][CH:10]=O.CCOC(C1CC(C(OCC)=O)=C(C)NC=1C)=O.N1C=CC=CC=1>CO.C(Cl)Cl>[CH2:9]([CH:2]1[C:3](=[O:7])[CH2:4][CH2:5][CH2:6][C:1]1=[O:8])[CH3:10]

Komponenten

7

Edukt 4

HCID 177AcetaldehydeHCID 1049PyridineHCID 104341,3-CyclohexanedioneHCID 70849Hantzsch ester

Produkt 1

HCID 108988052-Ethylcyclohexane-1,3-dioneAusbeute 69 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

1,3-Cyclohexanedione (10 g, 89.2 mmol), 40% aqueous CH3CHO (49.4 g, 445.9 mmol) were dissolved in methanol (40 mL) followed by addition of Hantzsch ester (22.7 g, 89.2 mmol) and pyridine (2.1 g, 18.74 mmol) under nitrogen. The resulting light yellow mixture was stirred at room temperature overnight, then concentrated to give crude product that was re-slurried in a mixture of CH2Cl2 (40 mL) and hexanes (60 mL) to furnish 2-ethyl-1,3-cyclohexanedione (8.6 g, 69%).

Aufarbeitung

  1. concentrationconcentrated
  2. customto give crude product that

Quellen und Nachweise

ORD-Eintrag
ord-0be1b85333fe4f2e857f2598abcd2658
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09073888B2

Notizen zur Reaktion

Wird geladen…