5-(2-piperazin-1-ylethyl)-2-benzofuran-1(3H)-one hydrochloride → 2,5-Difluoro-4-[2-[4-[2-(1-oxo-3H-isobenzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile
Reaktionsgleichung
Cl.[N:2]1([CH2:8][CH2:9][C:10]2[CH:19]=[CH:18][C:13]3[C:14](=[O:17])[O:15][CH2:16][C:12]=3[CH:11]=2)[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[F:20][C:21]1[CH:28]=[C:27]([CH2:29][CH:30]=O)[C:26]([F:32])=[CH:25][C:22]=1[C:23]#[N:24]>>[F:20][C:21]1[CH:28]=[C:27]([CH2:29][CH2:30][N:5]2[CH2:6][CH2:7][N:2]([CH2:8][CH2:9][C:10]3[CH:11]=[C:12]4[C:13](=[CH:18][CH:19]=3)[C:14](=[O:17])[O:15][CH2:16]4)[CH2:3][CH2:4]2)[C:26]([F:32])=[CH:25][C:22]=1[C:23]#[N:24]Komponenten
3
Versuchsvorschrift
2,5-Difluoro-4-[2-[4-[2-(1-oxo-3H-isobenzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile was prepared in a similar fashion to that described for the synthesis of Example 38 starting from 5-[2-(piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one hydrochloride and 2,5-difluoro-4-(2-oxoethyl)benzonitrile. LC-MS (IE, m/z): 412.1 [M+1]+. (0.23 μM)
Quellen und Nachweise
- ORD-Eintrag
- ord-071b6495a0814434a7f523cb23ae6635