Hydrogen chloride-ethyl acetate → N,N2,O-trimethyl-3-oxoserinamide hydrochloride

HRID 1519655Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1519655
[ClH:1].C(OCC)(=O)C.C(O[C:13]([N:15](C)[C@H:16]([C:21]([NH:23][CH3:24])=[O:22])[C:17](=[O:20])[O:18][CH3:19])=O)(C)(C)C>C(OCC)(=O)C>[ClH:1].[CH3:24][NH:23][C:21](=[O:22])[C@H:16]([C:17](=[O:20])[O:18][CH3:19])[NH:15][CH3:13]

Komponenten

4

Edukt 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86679245N2-(t-butoxycarbonyl)-N,N2,O-trimethyl-3-oxoserinamide2×

Produkt 1

HCID 86679246N,N2,O-trimethyl-3-oxoserinamide hydrochlorideAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A 4.0 mol/L-hydrochloric acid-ethyl acetate solution (0.13 L) was added to an ethyl acetate (0.19 L) solution of N2-(t-butoxycarbonyl)-N,N2,O-trimethyl-3-oxoserinamide (Intermediate 4-2, 62 g), and the mixture was stirred for 24 hours at room temperature. The precipitated solid was filtered off, and washed with ethyl acetate to obtain N,N2,O-trimethyl-3-oxoserinamide hydrochloride (Intermediate 5-2, white solid) (39 g, 84%).

Aufarbeitung

  1. filtrationThe precipitated solid was filtered off
  2. washwashed with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-d9099b4f59804f00836ac586b84f45b3
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09073821B2

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