1-Iodo-4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}benzene → 1-[1-(Cyclopropylamino)ethyl]-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene

Reaktionsgleichung

I[C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:20])[N:9]([CH:11]([C:16]([NH:18][CH3:19])=[O:17])[C:12]([O:14][CH3:15])=[O:13])[CH3:10])=[CH:4][CH:3]=1.[C:21]([C:23]1[CH:28]=[CH:27][C:26]([CH:29]([NH:31][CH:32]2[CH2:34][CH2:33]2)[CH3:30])=[CH:25][CH:24]=1)#[CH:22]>Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[Cu]I.C(Cl)(Cl)Cl>[CH:32]1([NH:31][CH:29]([C:26]2[CH:25]=[CH:24][C:23]([C:21]#[C:22][C:2]3[CH:7]=[CH:6][C:5]([C:8](=[O:20])[N:9]([CH:11]([C:16]([NH:18][CH3:19])=[O:17])[C:12]([O:14][CH3:15])=[O:13])[CH3:10])=[CH:4][CH:3]=3)=[CH:28][CH:27]=2)[CH3:30])[CH2:34][CH2:33]1