HCID 68782483, Verbindung → HCID 178434594, Verbindung

HRID 1519832Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1519832
[Cl:1][C:2]1[C:3]([C:8]2[NH:12][N:11]=[C:10]([CH3:13])[N:9]=2)=[C:4]([NH2:7])[S:5][CH:6]=1.[O:14]=[C:15]1[CH2:24][CH2:23][C:22]2[C:17](=[CH:18][CH:19]=[CH:20][N:21]=2)[N:16]1[CH2:25][C:26](O)=[O:27]>>[Cl:1][C:2]1[C:3]([C:8]2[NH:12][N:11]=[C:10]([CH3:13])[N:9]=2)=[C:4]([NH:7][C:26](=[O:27])[CH2:25][N:16]2[C:17]3[C:22](=[N:21][CH:20]=[CH:19][CH:18]=3)[CH2:23][CH2:24][C:15]2=[O:14])[S:5][CH:6]=1

Komponenten

3

Edukt 2

HCID 68782483HCID 68782483, VerbindungHCID 178434595HCID 178434595, Verbindung

Produkt 1

HCID 178434594HCID 178434594, Verbindung

Versuchsvorschrift

The title compound was prepared from 4-chloro-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-amine (69 mg, 321 umol) and 2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetic acid (82 mg, 397 umol) using protocol A. The residue was purified by HPLC. Method [8] Retention time 3.40 min by HPLC (M+=403 and 405) and (M+Na=425 and 427). 1H NMR (300 MHz, CDCl3) δ 8.39 (d, J=5.4 Hz, 1H), 7.67 (d, J=8.4 Hz, 1H), 7.49 (dd, J=8.4 and 5.4 Hz, 1H), 6.86 (s, 1H), 5.46 (broad s, 2H), 4.95 (s, 2H), 3.49 (m, 2H), 3.01 (m, 2H), 2.50 (s, 3H).

Aufarbeitung

  1. customThe residue was purified by HPLC

Quellen und Nachweise

ORD-Eintrag
ord-1fa3889641de408c95bef47ac9fb989e
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09073891B2

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