N-bromobutanimide → 5-Fluoro-2-iodo-4-trifluoromethyl-phenylamine

HRID 1519893Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1519893
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[C:9]([F:12])([F:11])[F:10])[NH2:5].C1C(=O)N([Br:20])C(=O)C1>C(Cl)Cl>[Br:20][C:6]1[CH:7]=[C:8]([C:9]([F:10])([F:11])[F:12])[C:2]([F:1])=[CH:3][C:4]=1[NH2:5]

Komponenten

4

Edukt 2

HCID 67184N-bromobutanimideHCID 27359144-Amino-2-fluorobenzotrifluoride

Produkt 1

HCID 687591875-Fluoro-2-iodo-4-trifluoromethyl-phenylamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To a stirring mixture of 3-fluoro-4-(trifluoromethyl)aniline (1.5 g) in DCM (12 mL) at room temperature was added dropwise a solution of NBS (1.5 g) in DCM (24 mL) over 15 min. The reaction mixture was stirred at rt for 1.5 h. The product mixture was concentrated under reduced pressure to one half of its original volumn. The white solid was filtered off and the crude product mixture was further purified via column chromatography. Retention time (min)=2.490, method [1], MS(ESI) 257.9 (M+H).

Aufarbeitung

  1. concentrationThe product mixture was concentrated under reduced pressure to one half of its original volumn
  2. filtrationThe white solid was filtered off
  3. customthe crude product mixture was further purified via column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-e7d8c773b0a4443084e5a46a84e9f879
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09073891B2

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