Trifluoroacetic acid → benzyl (1-(5-(4-((1R,2S)-2-(2,2-difluoroacetamido)-3-fluoro-1-hydroxypropyl)phenyl)pyridin-2-yl)ethyl)carbamate

HRID 1520548Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1520548
FC(F)(F)C(O)=O.[F:8][CH:9]([F:46])[C:10]([N:12]1[C@H:16]([CH2:17][F:18])[C@@H:15]([C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:26]=[CH:27][C:28]([CH:31]([NH:33][C:34](=[O:43])[O:35][CH2:36][C:37]4[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=4)[CH3:32])=[N:29][CH:30]=3)=[CH:21][CH:20]=2)[O:14]C1(C)C)=[O:11]>C(Cl)Cl>[F:46][CH:9]([F:8])[C:10]([NH:12][C@H:16]([CH2:17][F:18])[C@@H:15]([C:19]1[CH:20]=[CH:21][C:22]([C:25]2[CH:26]=[CH:27][C:28]([CH:31]([NH:33][C:34](=[O:43])[O:35][CH2:36][C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=3)[CH3:32])=[N:29][CH:30]=2)=[CH:23][CH:24]=1)[OH:14])=[O:11]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 86695502HCID 86695502, Verbindung

Produkt 1

HCID 86695504benzyl (1-(5-(4-((1R,2S)-2-(2,2-difluoroacetamido)-3-fluoro-1-hydroxypropyl)phenyl)pyridin-2-yl)ethyl)carbamateAusbeute 87,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Trifluoroacetic acid (2.2 mL) is added to the product of step 2, Example 95A (1.05 g, 1.94 mmol) in CH2Cl2 (39 mL) at 0° C. After 30 minutes the ice bath is removed and the mixture stirred at room temperature for 8 hours. Saturated NaHCO3 (60 mL) is added and the mixture extracted with CH2Cl2 (40 mL). The combined organics are dried over MgSO4, filtered and evaporated to give the title product (850 mg): m/z: 501.19.

Aufarbeitung

  1. customAfter 30 minutes the ice bath is removed
  2. additionSaturated NaHCO3 (60 mL) is added
  3. extractionthe mixture extracted with CH2Cl2 (40 mL)
  4. dry with materialThe combined organics are dried over MgSO4
  5. filtrationfiltered
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-bff7780a003f4fe5957bc3d5e207caa9
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09073894B2

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