Hydrochloric Acid → HCID 178479716, Verbindung

HRID 1520761Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1520761
[C:1]1([C:7]2[NH:11][N:10]=[C:9]([C:12]([NH:14][C:15]3[CH:20]=[CH:19][C:18]([C@@H:21]4[O:26][CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22]4)=[CH:17][CH:16]=3)=[O:13])[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:34]>O1CCOCC1>[ClH:34].[NH:23]1[CH2:24][CH2:25][O:26][C@@H:21]([C:18]2[CH:17]=[CH:16][C:15]([NH:14][C:12]([C:9]3[CH:8]=[C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[NH:11][N:10]=3)=[O:13])=[CH:20][CH:19]=2)[CH2:22]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 178452470HCID 178452470, Verbindung

Produkt 1

HCID 178479716HCID 178479716, VerbindungAusbeute 79,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel3×

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

To a solution of (S)-tert-butyl 2-(4-(5-phenyl-1H-pyrazole-3-carboxamido)phenyl)morpholine-4-carboxylate (120 mg, 268 μmol, Eq: 1.00) in dioxane (0.5 ml) was added 4M-HCl in dioxane (1.00 ml, 4.01 mmol, Eq: 15). The reaction mixture was stirred at 60° C. for 2 h. To the mixture was then added 10 ml of dioxane and the suspension was filtered off, washed with ether and dried under in high vacuum to give the target compound as a white solid (82.3 mg, 79.9%). MS (ISP): 349.2 ([M+H]+).

Aufarbeitung

  1. filtrationthe suspension was filtered off
  2. washwashed with ether
  3. customdried under in high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-2473f6310a1b493e9da1fad2c21722bd
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09073911B2

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