Trifluoroacetic acid → HCID 178522005, Verbindung
Reaktionsgleichung
[O:1]=[C:2]1[C:8]2=[N:9][C:10]3[CH:15]=[CH:14][C:13]([C:16]([NH:18][C:19]4[CH:24]=[CH:23][CH:22]=[C:21]([C:25]5[N:26]=[CH:27][N:28](C(C6C=CC=CC=6)(C6C=CC=CC=6)C6C=CC=CC=6)[CH:29]=5)[CH:20]=4)=[O:17])=[CH:12][C:11]=3[N:7]2[CH2:6][CH2:5][CH2:4][NH:3]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH:28]1[CH:29]=[C:25]([C:21]2[CH:20]=[C:19]([NH:18][C:16]([C:13]3[CH:14]=[CH:15][C:10]4[N:9]=[C:8]5[C:2](=[O:1])[NH:3][CH2:4][CH2:5][CH2:6][N:7]5[C:11]=4[CH:12]=3)=[O:17])[CH:24]=[CH:23][CH:22]=2)[N:26]=[CH:27]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of 1-oxo-N-[3-(1-trityl-1H-imidazol-4-yl)phenyl]-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]benzimidazole-8-carboxamide (53 mg, 0.08 mmol) in CH2Cl2 (3 mL) is added TFA (0.5 mL) and the solution is stirred for 2 h at room temperature. The solvent is evaporated and the residue treated with 0.1M aqueous NaOH solution. A brown solid is formed which is collected by filtration, washed with CH2Cl2, and dried to afford the title compound (26 mg, 80%).