Hydrogen Bromide → (R)-3-(3,4-Dihydroxyphenyl)-2-propylamine hydrobromide

Reaktionsgleichung

C[O:2][C:3]1[CH:4]=[C:5]([CH2:11][C@H:12]([NH2:14])[CH3:13])[CH:6]=[CH:7][C:8]=1[O:9]C.[BrH:15]>>[BrH:15].[OH:2][C:3]1[CH:4]=[C:5]([CH2:11][C@H:12]([NH2:14])[CH3:13])[CH:6]=[CH:7][C:8]=1[OH:9]

Komponenten

Edukt 2

HCID 260Hydrogen Bromide

HCID 117694083,4-Dma, (R)-

Produkt 1

HCID 67643451(R)-3-(3,4-Dihydroxyphenyl)-2-propylamine hydrobromide

Versuchsvorschrift

A solution of (R)-3-(3,4-dimethoxyphenyl)-2-propylamine hydrochloride1 (500 mg, 2.15 mMol) in hydrogen bromide (48%, 5 ml) was stirred at 100° C. under an argon atmosphere for 20 hours. After cooling, the solvent was evaporated and the residue was dried giving the title compound.

Aufarbeitung

temperatureAfter cooling
customthe solvent was evaporated
customthe residue was dried

Quellen und Nachweise

ORD-Eintrag: ord-a3c93df638364213adea34d2adfb06d5
Quelldatensatz: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05726165

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