Benzaldehyde → N-benzal-6-(methylthio)pyridine-3-amine

2-(methylthio)-5-aminopyridine (1 g, 7 mmol), benzaldehyde (0.76 g, 7 mmol), tetraisopropyl titanate (3 mL) and tetrahydrofuran (25 mL) were mixed and stirred to react at 70° C. for 24 hours. Saturated sodium carbonate solution was added into the reaction mixture, and the mixture was extracted with ethyl acetate for three times. The combined organic phase was dried with anhydrous sodium sulfate, filtered and concentrated to yield the residual (1.72 g), which was directly used in the next reaction step without purification.

1. customto react at 70° C. for 24 hours
2. extractionthe mixture was extracted with ethyl acetate for three times
3. dry with materialThe combined organic phase was dried with anhydrous sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customto yield the residual (1.72 g), which
7. customwas directly used in the next reaction step without purification

ORD-Eintrag

ord-8de93fd91f2344f3bfd0aaed68e6a7ec

Quelldatensatz

uspto-grants-2015_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09079876B2