3,5-Dichlorophenylboronic acid → (2RS,4R)-6-(3,5-Dichlorophenyl)-6',6'-difluoro-2-phenyl-6',7'-dihydro-2'H-spiro[chroman-4,5'-[1,4]oxazepin]-3'-amine
Reaktionsgleichung
Br[C:2]1[CH:3]=[C:4]2[C@@:11]3([C:17]([F:19])([F:18])[CH2:16][O:15][CH2:14][C:13]([NH2:20])=[N:12]3)[CH2:10][CH:9]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[O:8][C:5]2=[CH:6][CH:7]=1.[Cl:27][C:28]1[CH:29]=[C:30](B(O)O)[CH:31]=[C:32]([Cl:34])[CH:33]=1>>[Cl:27][C:28]1[CH:29]=[C:30]([C:2]2[CH:3]=[C:4]3[C@@:11]4([C:17]([F:19])([F:18])[CH2:16][O:15][CH2:14][C:13]([NH2:20])=[N:12]4)[CH2:10][CH:9]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[O:8][C:5]3=[CH:6][CH:7]=2)[CH:31]=[C:32]([Cl:34])[CH:33]=1Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
The cross coupling reaction of (2RS,4R)-6-bromo-6′,6′-difluoro-2-phenyl-6′,7′-dihydro-2′H-spiro[chroman-4,5′-[1,4]oxazepin]-3′-amine (intermediate C3.4) with 3,5-dichlorophenylboronic acid yielded the title compound (8% yield) as a white solid. MS (ISP): m/z=489.4 [M+H]+.