Hydrochloride methanol → 2-(1-(2-Hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione 2-(diethylamino)acetate hydrochloride

HRID 1525814Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1525814
[CH2:1]([N:3]([CH2:8][CH3:9])[CH2:4][C:5]([OH:7])=[O:6])[CH3:2].[OH:10][CH2:11][CH2:12][N:13]1[C:18](=[O:19])[CH2:17][CH2:16][CH:15]([N:20]2[C:28](=[O:29])[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[C:21]2=[O:30])[C:14]1=[O:31].[ClH:32].CO>C(Cl)Cl>[ClH:32].[CH2:1]([N:3]([CH2:8][CH3:9])[CH2:4][C:5]([OH:7])=[O:6])[CH3:2].[OH:10][CH2:11][CH2:12][N:13]1[C:18](=[O:19])[CH2:17][CH2:16][CH:15]([N:20]2[C:21](=[O:30])[C:22]3[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:28]2=[O:29])[C:14]1=[O:31]

Komponenten

4

Edukt 2

HCID 21893726Hydrochloride methanolHCID 692485852-(1-(2-Hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione 2-(diethylamino)acetate

Produkt 1

HCID 692459092-(1-(2-Hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione 2-(diethylamino)acetate hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The compound obtained from example 9 (76 mg) was dissolved in DCM (10 mL), and 15% HCl/methanol solution (10 mL) was added dropwise. The solvent was removed by rotary evaporation in vacuo to afford white solid (80 mg). Solubility of this compound in water was higher than 100 mg/mL.

Aufarbeitung

  1. customThe solvent was removed by rotary evaporation in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-7a028a4405a24593b8af150839450088
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09085563B2

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