Hydrochloric Acid → 2-Pyridin-2-yl-4-pyridin-3-yl-1,2-dihydro-3H-pyrazol-3-one

HRID 1526086Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1526086
C([O:3][C:4](=O)[CH:5]([C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1)[CH:6]=[N:7][NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1)C.C([O-])C.[Na+].Cl>C(O)C>[N:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[N:8]1[C:4](=[O:3])[C:5]([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)=[CH:6][NH:7]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 2723922Sodium ethoxideHCID 687052862-Pyridin-3-yl-3-(pyridin-2-ylhydrazono)propionic acid ethyl ester

Produkt 1

HCID 591869472-Pyridin-2-yl-4-pyridin-3-yl-1,2-dihydro-3H-pyrazol-3-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

3.95 g (13.9 mmol) of the compound from Example 3A are initially introduced into 80 ml ethanol under argon and 945 mg (13.9 mmol) sodium ethanolate are added in portions at RT. After stirring for 30 min, 13.9 ml 1 M hydrochloric acid are added dropwise. The precipitate which has separated out is filtered off with suction, washed with cold ethanol (20 ml) and with water (twice with 20 ml each time) and dried in vacuo. 2.80 g (85% of th.) of the title compound are obtained.

Aufarbeitung

  1. customThe precipitate which has separated out
  2. filtrationis filtered off with suction
  3. washwashed with cold ethanol (20 ml) and with water (twice with 20 ml each time) and
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-b697a569b0fa48d5ae2cc6492d83a688
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09085572B2

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