Hydrochloric Acid → Icotinib Hydrochloride

HRID 1526526Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1526526
[CH:1]#[C:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([NH:9][C:10]2[N:19]=[CH:18][N:17]=[C:16]3[C:11]=2[CH:12]=[C:13]2[O:29][CH2:28][CH2:27][O:26][CH2:25][CH2:24][O:23][CH2:22][CH2:21][O:20][C:14]2=[CH:15]3)[CH:8]=1.[ClH:30]>CO>[CH:1]#[C:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([NH:9][C:10]2[C:11]3[C:16](=[CH:15][C:14]4[O:20][CH2:21][CH2:22][O:23][CH2:24][CH2:25][O:26][CH2:27][CH2:28][O:29][C:13]=4[CH:12]=3)[N:17]=[CH:18][N:19]=2)[CH:8]=1.[ClH:30]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 22024915Icotinib

Produkt 1

HCID 44609731Icotinib Hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Icotinib (1000 mg) was added into 100 mL reaction flask and dissolved with 60 mL of methanol. The concentrated hydrochloric acid was added dropwise while stirring till PH was adjusted to 2.0. After its completion, the reaction mixture was filtered to give crude product. The crude product was further purified by recrystallization with isopropyl alcohol to give Icotinib hydrochloride (1000 mg).

Aufarbeitung

  1. filtrationAfter its completion, the reaction mixture was filtered
  2. customto give crude product
  3. customThe crude product was further purified by recrystallization with isopropyl alcohol

Quellen und Nachweise

ORD-Eintrag
ord-9e49f2bbef784368a34c6fcfab3981dd
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09085588B2

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