(1-Carbamoyl-1H-indol-3-yl)-acetic acid → (1-Carbamoyl-5-fluoro-1H-indol-3-yl)-acetic acid

HRID 1527201Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1527201
C(N1C2C(=CC=CC=2)C(CC(O)=O)=C1)(=O)N.C([O:19][C:20](=[O:35])[CH2:21][C:22]1[C:30]2[C:25](=[CH:26][CH:27]=[C:28]([F:31])[CH:29]=2)[N:24]([C:32](=[O:34])[NH2:33])[CH:23]=1)C>>[C:32]([N:24]1[C:25]2[C:30](=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)[C:22]([CH2:21][C:20]([OH:35])=[O:19])=[CH:23]1)(=[O:34])[NH2:33]

Komponenten

3

Edukt 2

HCID 68283440(1-Carbamoyl-1H-indol-3-yl)-acetic acidHCID 68284150(1-carbamoyl-5-fluoro-1H-indol-3-yl)-acetic acid ethyl ester

Produkt 1

HCID 68283615(1-Carbamoyl-5-fluoro-1H-indol-3-yl)-acetic acid

Versuchsvorschrift

was prepared in a similar manner as described in Scheme A8 Step B for (1-carbamoyl-1H-indol-3-yl)-acetic acid starting from (1-carbamoyl-5-fluoro-1H-indol-3-yl)-acetic acid ethyl ester. The crude product (yellowish solid) obtained after extractive work-up was used directly in the next step without purification. MS: 236.9 [M+H]+; tR (HPLC conditions b) 2.4 min.

Aufarbeitung

  1. customwas prepared in a similar manner

Quellen und Nachweise

ORD-Eintrag
ord-febffcbfb47c42c5aeda9d98a4956a5c
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09085555B2

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