Trifluoroacetic acid → (3-Acetyl-5-methyl-pyrazolo[3,4-c]pyridin-1-yl)-acetic acid

HRID 1527272Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1527272
C([O:5][C:6](=[O:21])[CH2:7][N:8]1[C:12]2=[CH:13][N:14]=[C:15]([CH3:17])[CH:16]=[C:11]2[C:10]([C:18](=[O:20])[CH3:19])=[N:9]1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:18]([C:10]1[C:11]2[C:12](=[CH:13][N:14]=[C:15]([CH3:17])[CH:16]=2)[N:8]([CH2:7][C:6]([OH:21])=[O:5])[N:9]=1)(=[O:20])[CH3:19]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 68283035(3-Acetyl-5-methyl-pyrazolo[3,4-c]pyridin-1-yl)-acetic acid tert-butyl ester

Produkt 1

HCID 68283539(3-Acetyl-5-methyl-pyrazolo[3,4-c]pyridin-1-yl)-acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of (3-acetyl-5-methyl-pyrazolo[3,4-c]pyridin-1-yl)-acetic acid tert-butyl ester (126 mg, 0.37 mmol) and TFA (0.171 mL, 2.22 mmol) in CH2Cl2 (5 mL) was stirred at RT for 24 h. Solvents were removed under reduced pressure, Et2O was added and the precipitate was filtered, washed with Et2O and dried under high vacuum. The material thus obtained was used without further purification in the next step. MS (UPLC/MS): 234 [M+H]+, 232 [M−H]−, 465 [2M−H]−; tR (HPLC conditions f): 0.53 min.

Aufarbeitung

  1. customSolvents were removed under reduced pressure, Et2O
  2. additionwas added
  3. filtrationthe precipitate was filtered
  4. washwashed with Et2O
  5. customdried under high vacuum
  6. customThe material thus obtained
  7. customwas used without further purification in the next step
  8. custom0.53 min.

Quellen und Nachweise

ORD-Eintrag
ord-51abe66e203b461bbaac33338cfa7462
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09085555B2

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