Trifluoroacetic acid → 1386457-64-2

HRID 1527287Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1527287
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([O:16]C(C)(C)C)=[O:15])[N:5]=1)(=[O:3])[NH2:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([OH:16])=[O:15])[N:5]=1)(=[O:3])[NH2:2]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 68283122Tert-butyl 2-(3-carbamoyl-1H-indazol-1-yl)acetate

Produkt 1

HCID 682833421386457-64-2

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of tert-butyl 2-(3-carbamoyl-1H-indazol-1-yl)acetate (3.42 g, 12.4 mmol) in CH2Cl2 (20 mL) was added TFA (10 mL, 130 mmol) and the resulting mixture was stirred at RT for 16 h. The reaction mixture was concentrated in vacuo, the residual solid was suspended in methanol and concentrated again in vacuo to give the title compound. MS (LC/MS): 220 [M+H]+; tR (HPLC conditions k): 1.79 min.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. concentrationconcentrated again in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-3a891d8fc85a4806af6de6af68923fb9
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09085555B2

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