Trifluoroacetic acid → 1H-Pyrazolo[3,4-c]pyridine-1-acetic acid, 3-(aminocarbonyl)-

HRID 1527291Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1527291
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][N:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([O:16]C(C)(C)C)=[O:15])[N:5]=1)(=[O:3])[NH2:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:1]([C:4]1[C:12]2[C:7](=[CH:8][N:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([OH:16])=[O:15])[N:5]=1)(=[O:3])[NH2:2]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 68284362tert-butyl 2-(3-carbamoyl-1H-pyrazolo[3,4-c]pyridin-1-yl)acetate

Produkt 1

HCID 682831141H-Pyrazolo[3,4-c]pyridine-1-acetic acid, 3-(aminocarbonyl)-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of tert-butyl 2-(3-carbamoyl-1H-pyrazolo[3,4-c]pyridin-1-yl)acetate (663 mg, 2.40 mmol) in CH2Cl2 (20 mL) was added TFA (10 mL, 130 mmol), and the resulting mixture was stirred at RT for 6 h. The reaction mixture was concentrated in vacuo, the residual solid was suspended in methanol and volatiles were removed again in vacuo to give the title compound.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customvolatiles were removed again in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-8cb66e40a0344627946f221bcf5fc74e
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09085555B2

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