Trifluoroacetic acid → (2S,4R)-2-Azidomethyl-4-fluoro-pyrrolidine

HRID 1527382Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1527382
C(OC([N:8]1[CH2:12][C@H:11]([F:13])[CH2:10][C@H:9]1[CH2:14][N:15]=[N+:16]=[N-:17])=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:15]([CH2:14][C@@H:9]1[CH2:10][C@@H:11]([F:13])[CH2:12][NH:8]1)=[N+:16]=[N-:17]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 86673832HCID 86673832, Verbindung

Produkt 1

HCID 86673833(2S,4R)-2-Azidomethyl-4-fluoro-pyrrolidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of (2S,4R)-2-azidomethyl-4-fluoro-pyrrolidine-1-carboxylic acid tert-butyl ester (600 mg, 2.45 mmol) in CH2Cl2 (2.5 mL) was added TFA (1.88 mL, 24.6 mmol) and the solution was stirred at RT for 2 h. CH2Cl2 was concentrated and the crude was dried under high vacuum to give the desired material which was used without further purification in the next step.

Aufarbeitung

  1. concentrationCH2Cl2 was concentrated
  2. customthe crude was dried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-68646736dd584fda86226b06b63909c7
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09085555B2

Notizen zur Reaktion

Wird geladen…