1,1-Dimethylethyl 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]propanoate → 3-(2-Aminoethoxy)propanoic acid

HRID 1527651Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1527651
C([O:5][C:6](=[O:20])[CH2:7][CH2:8][O:9][CH2:10][CH2:11][NH:12]C(OC(C)(C)C)=O)(C)(C)C>FC(F)(F)C(O)=O>[NH2:12][CH2:11][CH2:10][O:9][CH2:8][CH2:7][C:6]([OH:20])=[O:5]

Komponenten

3

Edukt 1

HCID 894222391,1-Dimethylethyl 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]propanoate

Produkt 1

HCID 144623893-(2-Aminoethoxy)propanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

3-(2-tert-Butoxycarbonylamino-ethoxy)-propionic acid tert-butyl ester (10 g) was dissolved in a 1:1 trifluoroacetic acid (TFA)/DCM mixture (100 mL) and stirred at room temperature for 1 h. The solvent was then removed on a rotary evaporator and the resulting oil was re-dissolved in DCM and concentrated to dryness. This process was repeated until minimal TFA scent remained before the oil was dried on high vacuum for several hours.

Aufarbeitung

  1. customThe solvent was then removed on a rotary evaporator
  2. dissolutionthe resulting oil was re-dissolved in DCM
  3. concentrationconcentrated to dryness
  4. customwas dried on high vacuum for several hours

Quellen und Nachweise

ORD-Eintrag
ord-79c3a0141fc3499580561f46adf7e903
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09089611B2

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