Potassium Carbonate → HCID 90410457, Verbindung

To a solution of 3-((3-fluoro-4-nitrophenoxy)methyl)-1-methyl-1H-pyrazole (143 mg, 0.573 mmol) in acetonitrile (10 mL) was added K2CO3 (317 mg, 2.3 mmol) followed by (2-methyl-4-(trifluoromethoxy)phenyl)methanamine (117 mg, 0.573 mmol). The mixture was stirred at 90° Celsius overnight. The reaction was cooled to RT and concentrated to dryness. The resulting residue was dissolved in DCM (50 mL) and washed with water (50 mL). The organic phase was concentrated to give the title compound. MS (ESI): mass calcd. for C20H19F3N4O4, 436.14; m/z found, 437 [M+H]+.

1. temperatureThe reaction was cooled to RT
2. concentrationconcentrated to dryness
3. dissolutionThe resulting residue was dissolved in DCM (50 mL)
4. washwashed with water (50 mL)
5. concentrationThe organic phase was concentrated

ORD-Eintrag

ord-0fbef858a0634cc7881ad70b9ca93086

Quelldatensatz

uspto-grants-2015_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09089569B2