N-{5-[2-chloro-5-(trifluoromethyl)phenyl]pyrazin-2-yl}-2,6-difluorobenzamide → N-[5-(2-Chloro-5-trifluoromethyl-phenyl)-pyrazin-2-yl]-2,6-difluoro-benzamide hydrochloride

HRID 1527998

Reaktionsgleichung

Reaktionsgleichung von HRID 1527998
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[C:12]1[N:13]=[CH:14][C:15]([NH:18][C:19](=[O:28])[C:20]2[C:25]([F:26])=[CH:24][CH:23]=[CH:22][C:21]=2[F:27])=[N:16][CH:17]=1>CO>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:9])([F:10])[F:11])=[CH:4][C:3]=1[C:12]1[N:13]=[CH:14][C:15]([NH:18][C:19](=[O:28])[C:20]2[C:25]([F:26])=[CH:24][CH:23]=[CH:22][C:21]=2[F:27])=[N:16][CH:17]=1

Komponenten

3

Edukt 1

HCID 11546102N-{5-[2-chloro-5-(trifluoromethyl)phenyl]pyrazin-2-yl}-2,6-difluorobenzamide

Produkt 1

HCID 86606870N-[5-(2-Chloro-5-trifluoromethyl-phenyl)-pyrazin-2-yl]-2,6-difluoro-benzamide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Compound 4 was prepared by suspending Compound 1 in methanol and bubbling HCl gas through the suspension until all solids went into solution. The solvent was then removed to give Compound 4, the HCl salt of Compound 1.

Aufarbeitung

  1. customCompound 4 was prepared
  2. custombubbling HCl gas through the suspension until all solids
  3. customThe solvent was then removed

Quellen und Nachweise

ORD-Eintrag
ord-a1f1e3306b6b4699b02a2cc3b536f641
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09090570B2

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