Dimethylformamide dimethyl acetal → HCID 86686550, Verbindung

HRID 1528058Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1528058
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([N:15]2[CH:19]=[C:18]([F:20])[C:17]([F:21])=[CH:16]2)[CH:12]=[CH:11][C:10]=1[NH:22][N:23]=[C:24]([C:29](=[O:33])[CH2:30][O:31][CH3:32])[C:25]([O:27][CH3:28])=[O:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:34]OC(OC)N(C)C>>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([N:15]2[CH:19]=[C:18]([F:20])[C:17]([F:21])=[CH:16]2)[CH:12]=[CH:11][C:10]=1[N:22]1[CH:34]=[C:30]([O:31][CH3:32])[C:29](=[O:33])[C:24]([C:25]([O:27][CH3:28])=[O:26])=[N:23]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 78373Dimethylformamide dimethyl acetalHCID 178496279HCID 178496279, Verbindung

Produkt 1

HCID 86686550HCID 86686550, Verbindung

Versuchsvorschrift

A mixture of methyl 2-{[2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl]hydrazono}-4-methoxy-3-oxobutanoate (4.85 g) and N,N-dimethylformamide dimethyl acetal (100 mL) was heated under reflux for 3 hr. The mixture was allowed to be cooled to room temperature, and the precipitate was collected by filtration, and recrystallized from methanol to give the title compound (4.57 g).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hr
  3. filtrationthe precipitate was collected by filtration
  4. customrecrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-73e61775898445eab5cf791643266ed4
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09090586B2

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