4-Chloro-3-fluorophenylboronic Acid → 5-(4-Chloro-3-fluorophenyl)-6-(2-methoxyethoxy)nicotinic acid
Reaktionsgleichung
Br[C:2]1[CH:3]=[C:4]([C:13]([OH:15])=[O:14])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][CH2:10][O:11][CH3:12].[Cl:16][C:17]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19][C:18]=1[F:26]>>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:2]2[C:7]([O:8][CH2:9][CH2:10][O:11][CH3:12])=[N:6][CH:5]=[C:4]([CH:3]=2)[C:13]([OH:15])=[O:14])=[CH:19][C:18]=1[F:26]Komponenten
3
Versuchsvorschrift
The title compound was synthesized in analogy to Example BQ using 5-bromo-6-(2-methoxyethoxy)-3-pyridinecarboxylic acid (CAN 912454-34-3) and B-(4-chloro-3-fluorophenyl)-boronic acid (CAN 137504-86-0) as starting materials; LC-MS (UV peak area/ESI) 100%, 324.0456 (M−H)−.
Quellen und Nachweise
- ORD-Eintrag
- ord-459c28aef93747d8bb5efc18517cff7a
- Quelldatensatz
- uspto-grants-2015_07