Thionyl Chloride → 3,5-Difluoropyridine-2-carbonyl chloride
Reaktionsgleichung
[F:1][C:2]1[C:3]([C:9]([OH:11])=O)=[N:4][CH:5]=[C:6]([F:8])[CH:7]=1.S(Cl)([Cl:14])=O>>[F:1][C:2]1[C:3]([C:9]([Cl:14])=[O:11])=[N:4][CH:5]=[C:6]([F:8])[CH:7]=1Komponenten
3
Versuchsvorschrift
A suspension of 5.00 g (31.4 mmol) of 3,5-difluoropyridine-2-carboxylic acid in thionyl chloride (21 ml) was heated to reflux for 5 h. The solution was concentrated, and the residue was twice taken up in a little toluene and concentrated again. This gave 3.80 g of a solid, which was reacted further directly without further purification.
Aufarbeitung
- temperaturewas heated
- temperatureto reflux for 5 h
- concentrationThe solution was concentrated
- concentrationconcentrated again
- customThis gave 3.80 g of a solid, which was reacted further directly without further purification
Quellen und Nachweise
- ORD-Eintrag
- ord-ab6b71e67d9c47dc8adac0426f5d3c0a
- Quelldatensatz
- uspto-grants-2015_07
- Patentnummer
- US09090609B2
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