Tetrafluoro-m-phenylenediamine dihydrochloride → Racemic 3-chloro-4-[(4-{[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one dihydrochloride

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Tetrafluoro-m-phenylenediamine dihydrochloride	HCID 149026	—
Edukt	Ether hydrochloride	HCID 10953452	—
Edukt	Racemic 3-chloro-4-[(4-{[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one	HCID 24871549	—
Lösungsmittel	Chloroform	HCID 6212	—
Produkt	Racemic 3-chloro-4-[(4-{[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one dihydrochloride	HCID 68685184	—

Reaktionsschritte

Racemic 3-chloro-4-[(4-{[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one was converted to the dihydrochloride by dissolving in chloroform and adding 1M HCl/diethyl ether then evaporating to dryness. MS as that of free base.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07732461B2
Quelldatensatz	uspto-grants-2010_06
ORD ID	ord-5c06d8d3ee3c47bbbd4173856818d6b2
Quellennotiz	uspto-grants-2010_06