Ammonia → 4-Bromo-2-fluorobenzimidamide hydrochloride

HRID 1530481Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1530481
[ClH:1].C(O[C:5](=[NH:14])[C:6]1[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][C:7]=1[F:13])C.[NH3:15]>>[ClH:1].[Br:12][C:9]1[CH:10]=[CH:11][C:6]([C:5]([NH2:14])=[NH:15])=[C:7]([F:13])[CH:8]=1

Komponenten

3

Edukt 2

HCID 222AmmoniaHCID 670507354-Bromo-2-fluoro-benzimidic acid ethyl ester hydrochloride

Produkt 1

HCID 534078914-Bromo-2-fluorobenzimidamide hydrochlorideAusbeute 100 %

Versuchsvorschrift

A mixture of 4-bromo-2-fluoro-benzimidic acid ethyl ester hydrochloride (20.3 g, 72 mmol) in IMS (250 mL) at 0-5° C. was saturated with NH3 (gas), and the flask sealed before allowing to warm to RT and stirring for 18 h. Solvent was removed in vacuo and the residue triturated in diethyl ether to give 4-Bromo-2-fluoro-benzamidine hydrochloride as a white solid (18.1 g, 100%). 1H NMR δ (ppm) (DMSO-d6): 9.26 (4H, s), 7.92-7.87 (1H, m), 7.71-7.62 (2H, m).

Aufarbeitung

  1. customthe flask sealed
  2. customSolvent was removed in vacuo
  3. customthe residue triturated in diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-885234a4e94d43f58288a762ffb98d1d
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09090628B2

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