HCID 22842862, Verbindung → HCID 22842859, Verbindung
Reaktionsgleichung
[F:1][C:2]([F:27])([C:22](=[O:26])[CH2:23][CH2:24][CH3:25])/[CH:3]=[CH:4]/[CH2:5][C@H:6]1[C@H:13]([O:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][O:16]2)[CH2:12][C@H:11]2[C@@H:7]1[CH2:8][C:9](=[O:21])[O:10]2>C(OCC)(=O)C.[C].[Pd]>[F:27][C:2]([F:1])([C:22](=[O:26])[CH2:23][CH2:24][CH3:25])[CH2:3][CH2:4][CH2:5][C@H:6]1[C@H:13]([O:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][O:16]2)[CH2:12][C@H:11]2[C@@H:7]1[CH2:8][C:9](=[O:21])[O:10]2Komponenten
4
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
5% Palladium-carbon (catalytic amount) was added into the solution of (1S,5R,6R,7R)-6-{(E)-4,4-difluoro-5-oxo-2-octenyl}-7-tetrahydropyranyloxy-2-oxabicyclo-[3.3.0]octan-3-one (4) (5.57 g) in ethyl acetate, and mixed at a room temperature for 7 hours under hydrogen gas atmosphere. The reaction solution was filtered, and the filtrate was concentrated under a reduced pressure to give the titled compound (5) as a crude product. Yield: 5.48 g (97.8%)