Hydrochloric Acid → 2-(2-Propoxyphenyl)-8-methylthiopurin-6-one
Reaktionsgleichung
[CH3:1]I.[CH2:3]([O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]1[N:21]=[C:20]2[C:16](=[N:17][C:18]([SH:22])=[N:19]2)[C:15](=[O:23])[N:14]=1)[CH2:4][CH3:5].[OH-].[Na+].Cl>>[CH2:3]([O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]1[N:21]=[C:20]2[C:16](=[N:17][C:18]([S:22][CH3:1])=[N:19]2)[C:15](=[O:23])[N:14]=1)[CH2:4][CH3:5]Komponenten
5
Versuchsvorschrift
Methyl iodide (0.5 g) was added to a stirred solution of 2-(2-propoxyphenyl)-8-mercaptopurin-6-one (1.0 g) in 1 Normal sodium hydroxide solution (8 ml). After 2.5 hours at room temperature the solution was neutralised with dilute hydrochloric acid to give the crude product which was recrystallised three times from aqueous ethanol to give the title compound, 0.32 g, m.p. 245-247° C.