HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3,4-dihydro-2H-pyrano[2,3-c]pyridine-6-carbaldehyde → HCID 68688100, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3,4-dihydro-2H-pyrano[2,3-c]pyridine-6-carbaldehyde | HCID 56640311 | — |
| Edukt | racemic 4-{[(3R,4S)-4-amino-3-hydroxy-1-piperidinyl]methyl}-3-chloro-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one | HCID 68685696 | — |
| Lösungsmittel | Dichloromethane methanol | HCID 21226129 | — |
| Produkt | HCID 68688100 | HCID 68688100 | 50% |
Reaktionsschritte
The free base of the title compound was prepared from racemic 4-{[(3R,4S)-4-amino-3-hydroxy-1-piperidinyl]methyl}-3-chloro-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one and 3,4-dihydro-2H-pyrano[2,3-c]pyridine-6-carbaldehyde (for a synthesis see WO2004058144, Example 126(e)) according to the general method of Example 24(b), chromatographing with dichloromethane/methanol/0.88 ammonia 95:5:0.5, in 50% yield.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07732461B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-3ad3ef35312f4916b8026dbedf1fb346 |
| Quellennotiz | uspto-grants-2010_06 |