Pyrrolidine → 4-[4-(4,4'-Dipentylbicyclohexyl-4-ylethynyl)-3-fluorophenylethynyl]-4-methoxy-4'-propyl-bicyclohexyl

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Pyrrolidine	HCID 31268	—
Edukt	4-Ethynyl-4-methoxy-4'-propylbicyclohexyl	HCID 18364508	—
Edukt	4-(4-Bromo-2-fluorophenylethynyl)-4,4'-dipentylbicyclohexyl	HCID 22013388	—
Katalysator	HCID 178418397	HCID 178418397	—
Produkt	4-[4-(4,4'-Dipentylbicyclohexyl-4-ylethynyl)-3-fluorophenylethynyl]-4-methoxy-4'-propyl-bicyclohexyl	HCID 22013390	—

Reaktionsschritte

Analogously to Example 4, 1.913 g of 4-(4-bromo-2-fluorophenylethynyl)-4,4′-dipentylbicyclohexyl are reacted with 0.997 g of 4-ethynyl-4-methoxy-4′-propylbicyclohexyl in the presence of 0.219 g of tetrakis(triphenylphosphine)palladium(0) and 5 ml of pyrrolidine, giving 4-[4-(4,4′-dipentylbicyclohexyl-4-ylethynyl)-3-fluorophenylethynyl]-4-methoxy-4′-propyl-bicyclohexyl (C 177 N (36) I, Δε −0.26, Δn −0.015).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US06203724B1
Quelldatensatz	uspto-grants-2001_03
ORD ID	ord-0950396a12044c6da6857bf0ebd79153
Quellennotiz	uspto-grants-2001_03