Hydrogen chloride-ethyl acetate → HCID 22013762, Verbindung

HRID 1532688Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1532688
[ClH:1].C(OCC)(=O)C.[CH3:8][N:9]([CH3:47])[CH2:10][CH2:11][CH2:12][N:13]1[C:17]2[CH:18]=[CH:19][C:20]([C:22]([NH:24][CH3:25])=[O:23])=[CH:21][C:16]=2[N:15]=[C:14]1[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46]>C(OCC)(=O)C.C(O)C>[ClH:1].[CH3:47][N:9]([CH3:8])[CH2:10][CH2:11][CH2:12][N:13]1[C:17]2[CH:18]=[CH:19][C:20]([C:22]([NH:24][CH3:25])=[O:23])=[CH:21][C:16]=2[N:15]=[C:14]1[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46]

Komponenten

5

Edukt 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 22013763HCID 22013763, Verbindung

Produkt 1

HCID 22013762HCID 22013762, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

4N Hydrochloric acid/ethyl acetate solution (0.89 ml) was added to a solution containing 1-[3-(dimethylamino)propyl]-2-henicosyl-N-methyl-1H-benzimidazole-5-carboxamide (1.818 g) in a mixture of ethyl acetate (18 ml) and ethanol (1.8 ml). After being stirred for 30 minutes at room temperature, the reaction mixture was concentrated. The residue was recrystallized with the mixed solution of ethyl acetate-ethanol, thereby yielding the entitled compound (1.611 g) as white crystals.

Aufarbeitung

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized with the mixed solution of ethyl acetate-ethanol

Quellen und Nachweise

ORD-Eintrag
ord-7c4bd62862fc49ad97d6b1d408b68261
Quelldatensatz
uspto-grants-2001_03
Patentnummer
US06204264B1

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