Hydrogen chloride-ethyl acetate → HCID 22013777, Verbindung

HRID 1532692Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1532692
[ClH:1].C(OCC)(=O)C.[CH3:8][N:9]([CH3:42])[CH2:10][CH2:11][N:12]1[C:16]2[CH:17]=[CH:18][C:19]([C:21]([NH:23][CH3:24])=[O:22])=[CH:20][C:15]=2[N:14]=[C:13]1[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41]>C(OCC)(=O)C.C(O)C>[ClH:1].[CH3:8][N:9]([CH3:42])[CH2:10][CH2:11][N:12]1[C:16]2[CH:17]=[CH:18][C:19]([C:21]([NH:23][CH3:24])=[O:22])=[CH:20][C:15]=2[N:14]=[C:13]1[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41]

Komponenten

5

Edukt 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 22013765HCID 22013765, Verbindung

Produkt 1

HCID 22013777HCID 22013777, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

4N Hydrochloric acid/ethyl acetate solution (1.24 ml) was added to a solution containing 1-[2-(dimethylamino)ethyl]-2-heptadecyl-N-methyl-1H-benzimidazole-5-carboxamide (2.207 g) in a mixture of ethyl acetate (22 ml) and ethanol (2 ml). After being stirred for 30 minutes while being cooled with ice, the reaction mixture was concentrated. The residue was recrystallized with the mixed solution of ethyl acetate-ethanol, thereby yielding the entitled compound (1.751 g) as white crystals.

Aufarbeitung

  1. temperaturewhile being cooled with ice
  2. concentrationthe reaction mixture was concentrated
  3. customThe residue was recrystallized with the mixed solution of ethyl acetate-ethanol

Quellen und Nachweise

ORD-Eintrag
ord-fe0ea16a2d7a42b3ba1d89e5c62176fb
Quelldatensatz
uspto-grants-2001_03
Patentnummer
US06204264B1

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