HCID 57423122, Verbindung → Racemic methyl 3-{(2S)-2-[({[(1,1-dimethylethyl)oxy]carbonyl}amino)methyl]-4-morpholinyl}-2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]propanoate
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[C:12](=[CH2:17])[C:13]([O:15][CH3:16])=[O:14])=[N:9][C:8]([O:18][CH3:19])=[CH:7][CH:6]=2.CC([N:24]([CH2:28][C@@H:29]1[O:34][CH2:33][CH2:32][NH:31][CH2:30]1)[C:25](=[O:27])[O-:26])(C)C>>[CH3:2][C:11]([O:26][C:25]([NH:24][CH2:28][C@@H:29]1[O:34][CH2:33][CH2:32][N:31]([CH2:17][CH:12]([C:11]2[C:10]3[C:5](=[CH:6][CH:7]=[C:8]([O:18][CH3:19])[N:9]=3)[N:4]=[CH:3][C:2]=2[F:1])[C:13]([O:15][CH3:16])=[O:14])[CH2:30]1)=[O:27])([CH3:12])[CH3:10]Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
This compound was prepared from methyl 2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]-2-propenoate and 1,1-dimethylethyl[(2R)-2-morpholinylmethyl]carbamate according to the general method of Example 2(d), in 100% yield.