Methanol → HCID 15029531, Verbindung

HRID 1534312Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1534312
[OH:1][C:2]([CH2:4][O:5][NH:6][C:7](=[O:26])[CH:8]([O:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:18]2[C:23]([Cl:24])=[CH:22][C:21]([Cl:25])=[CH:20][N:19]=2)=[CH:13][CH:12]=1)[CH3:9])=O.[N+](=[CH2:29])=[N-].[CH3:30][OH:31]>>[CH3:30][O:31][C:2]([CH2:4][O:5][N:6]([CH3:29])[C:7](=[O:26])[CH:8]([O:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:18]2[C:23]([Cl:24])=[CH:22][C:21]([Cl:25])=[CH:20][N:19]=2)=[CH:13][CH:12]=1)[CH3:9])=[O:1]

Komponenten

4

Edukt 3

HCID 887MethanolHCID 9550DiazomethaneHCID 15029529N-hydroxycarbonylmethoxy-2-[4-(3,5-dichloro-2-pyridyloxy)phenoxy]propionamide

Produkt 1

HCID 15029531HCID 15029531, Verbindung

Versuchsvorschrift

To a solution of N-hydroxycarbonylmethoxy-2-[4-(3,5-dichloro-2-pyridyloxy)phenoxy]propionamide (Compound No. 37 as obtained in Example 3) (0.38 g) in methanol (1 ml), there was added an etheral solution of diazomethane until the yellow color remained, and the resultant mixture was allowed to stand for 10 minutes. The reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel chromatography (eluent: 88% hexane :12% ethyl acetate) to give N-methoxycarbonylmethoxy-N-methyl-2-[4-(3,5-dichloro-2-pyridyloxy)phenoxy]propionamide (0.35 g). Yield, 86%.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customThe residue was purified by silica gel chromatography (eluent: 88% hexane :12% ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-433b977421394548bb40fc871dcd23cf
Quelldatensatz
uspto-grants-1992_02
Patentnummer
US05089043

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