Sodium Hydroxide → HCID 10043588, Verbindung

HRID 1534481Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1534481
[C:1]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1Cl)=[CH:13][CH:12]=[CH:11][C:10]=2[CH2:17][O:18]C(=O)C1C=CC=CC=1)(=[O:5])[CH:2]([CH3:4])[CH3:3].[F:27][C:28]1[CH:34]=[CH:33][C:31]([NH2:32])=[C:30]([CH3:35])[CH:29]=1.[OH-].[Na+]>O1CCOCC1.CO>[C:1]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:32][C:31]1[CH:33]=[CH:34][C:28]([F:27])=[CH:29][C:30]=1[CH3:35])=[CH:13][CH:12]=[CH:11][C:10]=2[CH2:17][OH:18])(=[O:5])[CH:2]([CH3:3])[CH3:4]

Komponenten

6

Edukt 3

HCID 14798Sodium HydroxideHCID 679824-Fluoro-2-methylanilineHCID 10384366HCID 10384366, Verbindung

Produkt 1

HCID 10043588HCID 10043588, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A solution of 3-isobutyryl-4-chloro-8-benzoyloxymethylquinoline (1.84 g, 5 mmol) and 4-fluoro-2-methylaniline (0.78 ml, 7 mmol) in dioxan (25 ml) was heated at reflux for 2 hours, then the solvent evaporated. A solution of sodium hydroxide (0.8 g, 20 mmol) in methanol (50 ml) was added and the mixture stirred at room temperature for 1.5 hours. The resulting precipitate was filtered off and recrystallized from methanol to give (0.48 g, 27%), m.p. 139°-140°.

Aufarbeitung

  1. temperatureat reflux for 2 hours
  2. customthe solvent evaporated
  3. filtrationThe resulting precipitate was filtered off
  4. customrecrystallized from methanol
  5. customto give (0.48 g, 27%), m.p. 139°-140°

Quellen und Nachweise

ORD-Eintrag
ord-113c4a8962444042b7ab0949e43a9e1b
Quelldatensatz
uspto-grants-1992_02
Patentnummer
US05089504

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