Ethyl bromoacetate → HCID 53700452, Verbindung

HRID 1534684Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1534684
[H-].[Na+].[CH2:3]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH:16]=[CH:17][C:18]([C:20]1[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH:28]=[C:29]([CH3:31])[CH3:30])=[CH:22][C:21]=1[OH:32])=[O:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].Br[CH2:34][C:35]([O:37][CH2:38][CH3:39])=[O:36]>CN(C=O)C>[CH2:38]([O:37][C:35]([CH2:34][O:32][C:21]1[CH:22]=[C:23]([O:26][CH2:27][CH:28]=[C:29]([CH3:31])[CH3:30])[CH:24]=[CH:25][C:20]=1[C:18](=[O:19])[CH:17]=[CH:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])=[O:36])[CH3:39]

Komponenten

5

Edukt 3

HCID 7748Ethyl bromoacetateHCID 24758Sodium hydrideHCID 54231235HCID 54231235, Verbindung

Produkt 1

HCID 53700452HCID 53700452, VerbindungAusbeute 53,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel2×

Versuchsvorschrift

To a suspension of 310 mg of 60% oily sodium hydride in 10 ml of dry DMF was added dropwise a solution of 2.8 g of 2-n-heptyl-2'-hydroxy-4'-(3-methyl-2-butenyloxy)chalcone in 10 ml of DMF with ice cooling. Then, 1.2 g of ethyl bromoacetate was added, and the mixture was stirred at room temperature for an hour. After neutralization with dilute hydrochloric acid, the mixture was extracted with ethyl acetate. The organic layer was washed with water and dried, and the solvent was evaporated under reduced pressure. The residue was chromatographed on silica gel column with n-hexane containing 1% ethyl acetate to give 1.83 g of 2'-ethoxycarbonylmethoxy-2-n-heptyl-4'-(3-methyl-2-butenyloxy)-chalcone. To a solution of this compound in 30 ml of ethanol was added 15 ml of 10% aqueous potassium carbonate solution, and the mixture was stirred at 60° C. for 4.5 hours. After neutralization with dilute hydrochloric acid with ice cooling, the precipitated solid was collected by filtration and recrystallized from ethanol to give 1.23 g of 2'-carboxymethoxy-2-n-heptyl-4'-(3-methyl-2-butenyloxy)chalcone as pale yellow plates.

Aufarbeitung

  1. extractionAfter neutralization with dilute hydrochloric acid, the mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with water
  3. customdried
  4. customthe solvent was evaporated under reduced pressure
  5. customThe residue was chromatographed on silica gel column with n-hexane containing 1% ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-6d63aa86a77149b683f7a0eb60010c61
Quelldatensatz
uspto-grants-1992_02
Patentnummer
US05089654

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