Potassium Hydroxide → HCID 54478415, Verbindung

HRID 1534686Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1534686
[OH:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH:10]=[C:11]([CH3:13])[CH3:12])[CH:5]=[CH:4][C:3]=1[C:14](=[O:16])[CH3:15].[C:17]([C:21]1[CH:28]=[CH:27][C:24]([CH:25]=O)=[CH:23][CH:22]=1)([CH3:20])([CH3:19])[CH3:18].[OH-].[K+]>C(O)C>[C:17]([C:21]1[CH:22]=[CH:23][C:24]([CH:25]=[CH:15][C:14]([C:3]2[CH:4]=[CH:5][C:6]([O:8][CH2:9][CH:10]=[C:11]([CH3:12])[CH3:13])=[CH:7][C:2]=2[OH:1])=[O:16])=[CH:27][CH:28]=1)([CH3:20])([CH3:19])[CH3:18]

Komponenten

5

Edukt 3

HCID 14797Potassium HydroxideHCID 703244-tert-ButylbenzaldehydeHCID 109329682'-Hydroxy-4'-(3-methyl-2-butenyloxy)acetophenone

Produkt 1

HCID 54478415HCID 54478415, VerbindungAusbeute 53 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

To a solution of 54.4 g of 2'-hydroxy-4'-(3-methyl-2-butenyloxy)acetophenone and 40.0 g of 4-t-butylbenzaldehyde in 1000 ml of ethanol was added 81.2 g of potassium hydroxide, and the mixture was stirred at 40° C. for 19 hours. After neutralization with dilute hydrochloric acid, the resulting precipitate was collected by filtration, washed with water, dried and recrystallized from isopropanol to give 47.6 g of 4-t-butyl-2'-hydroxy-4'-(3-methyl-2-butenyloxy)chalcone as a yellow powder.

Aufarbeitung

  1. filtrationAfter neutralization with dilute hydrochloric acid, the resulting precipitate was collected by filtration
  2. washwashed with water
  3. customdried
  4. customrecrystallized from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-b03e67acc1e84ed887aeeccf08ce558d
Quelldatensatz
uspto-grants-1992_02
Patentnummer
US05089654

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