Methyl Thioglycolate → 5,7-Difluoro-benzo[B]thiophene-2-carboxylic acid methyl ester

Beteiligte Stoffe

Reaktionsschritte

Using 3.94 g (24.6 mmol) of 2,3,5-trifluorobenzaldehyde, 1.48 g (36.9 mmol) of sodium hydride (60% pure) and 2.88 g (27.1 mmol) of methyl mercaptoacetate, 3.58 g (56% of theory) of the title compound are obtained in a purity of 89%. Recrystallization from methanol gives the product in a purity of 97%.

Herkunft & Nachweise