Sodium Bicarbonate → (3,3-Diethoxy-propyl)-carbamic acid allyl ester

HRID 15529

Reaktionsgleichung

Reaktionsgleichung von HRID 15529
[C:1](Cl)(=[O:5])[CH2:2][CH:3]=C.[CH2:7]([O:9][CH:10]([O:14][CH2:15][CH3:16])[CH2:11][CH2:12][NH2:13])[CH3:8].[C:17]([O-])(O)=[O:18].[Na+]>C(Cl)Cl>[CH2:2]([O:3][C:17](=[O:18])[NH:13][CH2:12][CH2:11][CH:10]([O:14][CH2:15][CH3:16])[O:9][CH2:7][CH3:8])[CH:1]=[CH2:5]

Komponenten

5

Edukt 3

HCID 516892Sodium BicarbonateHCID 5210291-Amino-3,3-diethoxypropaneHCID 10975427But-3-enoyl Chloride

Produkt 1

HCID 86605042(3,3-Diethoxy-propyl)-carbamic acid allyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

But-3-enoyl chloride (930 uL, 8.84 mmol) was added slowly to a rapidly stirring mixture of 3,3-diethoxy-propylamine (1.0 g, 6.80 mmol) and NaHCO3 (2 mL of 0.6 M NaHCO3 in water) in DCM (100 mL). The reaction was stirred at room temperature overnight, then partitioned between water and DCM. The organic layer was washed several times with water and concentrated to give the crude sub-title compound that was used without further purification.

Aufarbeitung

  1. stirringThe reaction was stirred at room temperature overnight
  2. custompartitioned between water and DCM
  3. washThe organic layer was washed several times with water
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-233d52f44e6349a7a7bc1dd57e6b77de
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732618B2

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