1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(3-isopropylisoxazol-5-yl)urea → 1-(3-(2-Fluoropropan-2-yl)isoxazol-5-yl)-3-(3-(6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yloxy)phenyl)urea

Reaktionsgleichung

[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([O:18][c:19]3[cH:20][c:21]([NH2:22])[cH:23][cH:24][cH:25]3)[n:7][cH:8][n:9][c:10]2[cH:11][c:12]1[O:13][CH2:14][CH2:15][O:16][CH3:17].[CH3:45][O:46][c:47]1[cH:48][c:49]2[c:50]([cH:51][c:52]1[O:53][CH3:54])[n:55][cH:56][n:57][c:58]2[O:59][c:60]1[cH:61][c:62]([NH:63][C:64]([NH:65][c:66]2[o:67][n:68][c:69]([CH:70]([CH3:71])[CH3:72])[cH:73]2)=[O:74])[cH:75][cH:76][cH:77]1.[F:26][C:27]([CH3:28])([CH3:29])[c:30]1[n:31][o:32][c:33]([NH:35][C:36]([O:37][c:39]2[cH:40][cH:41][cH:42][cH:43][cH:44]2)=[O:38])[cH:34]1>>[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([O:18][c:19]3[cH:20][c:21]([NH:22][C:36]([NH:35][c:33]4[o:32][n:31][c:30]([C:27]([F:26])([CH3:28])[CH3:29])[cH:34]4)=[O:37])[cH:23][cH:24][cH:25]3)[n:7][cH:8][n:9][c:10]2[cH:11][c:12]1[O:13][CH2:14][CH2:15][O:16][CH3:17]