Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Acetone | HCID 180 | — |
| Edukt | Phosphoric Acid | HCID 1004 | — |
| Edukt | Oseltamivir tartrate | HCID 16667738 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | Tamiflu | HCID 78000 | 56,3% |
Reaktionsschritte
Oseltamivir tartrate (13 gm, obtained in example 3) is added to acetone (150 ml) at 25-30° C., the solution of H3PO4 (3.5 gm) in 40 ml of ethanol is added to the contents and then stirred for 1 hour 30 minutes at 25-30° C. Filtered the solid, washed with 30 ml of acetone and dried to yield 6.5 gm of oseltamivir phosphate (HPLC purity: 99.8%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US07732632B2 |
|---|
| Quelldatensatz | uspto-grants-2010_06 |
|---|
| ORD ID | ord-958f4ca71a0043ed81f947dbc750f7d2 |
|---|
| Quellennotiz | uspto-grants-2010_06 |
|---|
