5-(4-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile → 5-(4-Chlorophenyl)-2-hydroxypyridine
Reaktionsgleichung
C([C:3]1[C:4](=[O:16])[NH:5][CH:6]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[CH:8]=1)#N>OP(O)(O)=O>[Cl:15][C:12]1[CH:11]=[CH:10][C:9]([C:7]2[CH:8]=[CH:3][C:4](=[O:16])[NH:5][CH:6]=2)=[CH:14][CH:13]=1Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 3-cyano-5-(4-chlorophenyl)-2-pyridinone (4.6 g) and 85% H3PO4 (60 ml) was heated at reflux for 16 hours. The resulting mixture was cooled to room temperature, poured into ice/water and filtered yielding 3.1 g of 5-(4-chlorophenyl)-2-pyridinone as a yellow solid.
Aufarbeitung
- temperaturewas heated
- temperatureat reflux for 16 hours
- filtrationfiltered
Quellen und Nachweise
- ORD-Eintrag
- ord-1a4f37788b1a484282d9cf4c25552db7
- Quelldatensatz
- uspto-grants-1998_03
- Patentnummer
- US05726176
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