4-Piperidinol, 1-(1H-indol-3-yloxoacetyl)-4-phenyl- → HCID 12589402, Verbindung

HRID 1576485Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1576485
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10](=O)[C:11]([N:13]2[CH2:18][CH2:17][C:16]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)([OH:19])[CH2:15][CH2:14]2)=O)=[CH:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[OH:19][C:16]1([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:15][CH2:14][N:13]([CH2:11][CH2:10][C:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[NH:1][CH:2]=2)[CH2:18][CH2:17]1

Komponenten

4

Edukt 2

HCID 2055944-Piperidinol, 1-(1H-indol-3-yloxoacetyl)-4-phenyl-HCID 21226445Aluminium lithium hydride

Produkt 1

HCID 12589402HCID 12589402, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

A solution of 17.0 g. (0.049 mole) of 1-(indol-3-ylglyoxyloyl)-4-phenyl-4-piperidinol in 100 ml. of tetrahydrofuran was reduced in the usual way with 7.4 g. (0.195 mole) of lithium aluminum hydride in 200 ml. of tetrahydrofuran. After the usual workup 11.6 g. of oil was obtained which was crystallized from benzene-isooctane yielding 8.6 g. (55%) of product which melted at 133°-137° C. Another recrystallization from benzene raised the melting point to 137°-139° C. The analytical sample melted at 137°-139° C.

Aufarbeitung

  1. customof oil was obtained which
  2. customwas crystallized from benzene-isooctane yielding 8.6 g
  3. customAnother recrystallization from benzene
  4. temperatureraised the melting point to 137°-139° C

Quellen und Nachweise

ORD-Eintrag
ord-8a2e53330eaf4964a3f569b999ddd63b
Quelldatensatz
uspto-grants-1976_09
Patentnummer
USRE028973

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