1-Acetylcyclohexene → 2,3,4,4a,6,7,11b,12,13,13a-decahydro-9,10-dimethoxy-1H-dibenzo[a,f]quinolizin-13-one

HRID 1576772

Reaktionsgleichung

Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[O:14][CH3:15])[CH:10]=[N:9][CH2:8][CH2:7]2.[CH3:16][C:17]([C:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH:20]=1)=[O:18].C1C2C(=CC=CC=2)CCN=1.CC(C1CCCC=1)=O>>[CH3:2][O:3][C:4]1[C:13]([O:14][CH3:15])=[CH:12][C:11]2[CH:10]3[N:9]([CH2:8][CH2:7][C:6]=2[CH:5]=1)[CH:20]1[CH2:21][CH2:22][CH2:23][CH2:24][CH:19]1[C:17](=[O:18])[CH2:16]3

Komponenten

Edukt 4

HCID 136121-Acetylcyclohexene

HCID 767053,4-Dihydroisoquinoline

HCID 1929251-Acetylcyclopentene

HCID 27246643,4-Dihydro-6,7-dimethoxyisoquinoline hydrochloride

Produkt 1

HCID 127744922,3,4,4a,6,7,11b,12,13,13a-decahydro-9,10-dimethoxy-1H-dibenzo[a,f]quinolizin-13-one

Versuchsvorschrift

When in Example 6 appropriate amounts of 3,4-dihydro-6,7 -dimethoxyisoquinoline hydrochloride and 1-cyclohexen-1-yl methyl ketone respectively are substituted for 3,4-dihydroisoquinoline and 1-cyclopenten-1-yl methyl ketone, 2,3,4,4a,6,7,11b,12,13,13a-decahydro-9,10-dimethoxy-1H-dibenzo[a,f]quinolizin-13-one is obtained, M.P. 129°-141°C.

Quellen und Nachweise

ORD-Eintrag: ord-b50c4a3134534b4eb5d8e13656d6a958
Quelldatensatz: uspto-grants-1976_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US03983122

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