Hydrochloric Acid → 3alpha-Hydroxy-21-morpholino-5alpha-pregnane-11,20-dione hydrochloride

HRID 1576777Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1576777
[OH:1][C@@H:2]1[CH2:27][CH2:26][C@@:25]2([CH3:28])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:24]2[C:23](=[O:29])[CH2:22][C@@:21]2([CH3:30])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:20])[CH2:13][N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[CH2:3]1.[ClH:31]>C(O)C>[ClH:31].[OH:1][C@@H:2]1[CH2:27][CH2:26][C@@:25]2([CH3:28])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:24]2[C:23](=[O:29])[CH2:22][C@@:21]2([CH3:30])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:20])[CH2:13][N:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)[CH2:3]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 867340213alpha-Hydroxy-21-morpholino-5alpha-pregnane-11,20-dione

Produkt 1

HCID 867340253alpha-Hydroxy-21-morpholino-5alpha-pregnane-11,20-dione hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 3α-hydroxy-21-morpholino-5α-pregnane-11,20-dione (104.14 mg., 0.25 mmole) in ethanol (4 ml.) was treated with 0.1N hydrochloric acid (2.5 ml., 0.25 mmole). The solution was evaporated in vacuo and then treated with water (5 ml.). The undissolved solid (8.4 mg.) was removed by filtration and the filtrate was made up to 9.6 ml. with distilled water to give a 1% aqueous solution of the title compound.

Aufarbeitung

  1. customThe solution was evaporated in vacuo
  2. additiontreated with water (5 ml.)
  3. customThe undissolved solid (8.4 mg.) was removed by filtration

Quellen und Nachweise

ORD-Eintrag
ord-740cbae19b3341ea8e4cd3ca7830c7af
Quelldatensatz
uspto-grants-1976_09
Patentnummer
US03983111

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