Phenylethanolamine → alpha-(((4,5-Dihydro-1H-imidazol-2-yl)amino)methyl)benzyl alcohol

HRID 1576839

Reaktionsgleichung

Reaktionsgleichung von HRID 1576839
[OH:1][CH:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:3][NH2:4].N([C:15]1[NH:16][CH2:17][CH2:18][N:19]=1)[N+]([O-])=O.C1(C)C(C)=CC=CC=1>CC(C)=O>[OH:1][CH:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:3][NH:4][C:15]1[NH:19][CH2:18][CH2:17][N:16]=1

Komponenten

5

Edukt 3

HCID 1000PhenylethanolamineHCID 7237O-XyleneHCID 4100422-Nitroamino-2-imidazoline

Produkt 1

HCID 103775alpha-(((4,5-Dihydro-1H-imidazol-2-yl)amino)methyl)benzyl alcohol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Reaktionsbedingungen

Temperatur
160 °C

Versuchsvorschrift

A mixture of 15.8 parts β-hydroxy-phenethyl-amine, 13 parts 2-nitramino-2-imidazoline and 8 parts xylene is stirred and heated for 30 minutes at 160°C. (oil-bath). After cooling the reaction mixture to a temperature of about 70°C., there are added 40 parts acetone. The whole is filtered warm and after cooling the filtrate to room temperature, the precipicated product is filtered off and dried, yielding 2-(β-hydroxy-phenethyl-amino)-2-imidazoline; m.p. 147°-149°C.

Aufarbeitung

  1. temperatureAfter cooling the reaction mixture to a temperature of about 70°C., there
  2. filtrationThe whole is filtered
  3. temperaturewarm
  4. temperatureafter cooling the filtrate to room temperature
  5. filtrationthe precipicated product is filtered off
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-89c90c3b4a1241ecba9222bfc6b6ec7a
Quelldatensatz
uspto-grants-1976_09
Patentnummer
US03983133

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