(1S,2R)-(+)-Norephedrine → alpha-[1-(2-Imidazolin-2-ylamino)ethyl]benzyl alcohol

Beteiligte Stoffe

Reaktionsschritte

A mixture of 6.5 parts of α-(1-aminoethyl)benzyl alcohol (also known as morephedrine), 5.2 parts of 2-(nitramino)-2-imidazoline and 8 parts of xylene is stirred for 30 minutes while heating at 160°-170°C. The reaction mixture is cooled and diluted with acetone. The latter is removed in vacuo, yielding α-[1-(2-imidazolin-2-ylamino)-ethyl]benzyl alcohol as an oily residue.

Herkunft & Nachweise