HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1576844Erstellt: 24. Oktober 2026
Benzene → p-Fluoro-alpha-(2-imidazolin-2-ylaminomethyl)benzyl alcohol
https://huagongshe.com/de/reaction/1576844
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Benzene | HCID 241 | — |
| Edukt | O-Xylene | HCID 7237 | — |
| Edukt | 2-Amino-1-(4-fluorophenyl)ethan-1-ol | HCID 9827 | — |
| Edukt | 2-Nitroamino-2-imidazoline | HCID 410042 | — |
| Lösungsmittel | Acetone | HCID 180 | — |
| Produkt | p-Fluoro-alpha-(2-imidazolin-2-ylaminomethyl)benzyl alcohol | HCID 54097200 | — |
Reaktionsschritte
To a solution of 6.5 parts of α-(aminomethyl)-p-fluorobenzyl alcohol in 8 parts of xylene are added 5.2 parts of 2-(nitramino)-2-imidazoline. The mixture is heated in an oil-bath to about 160°C. till gas-evolution is ceased (about 15 minutes). The reaction mixture is cooled and treated with benzene and acetone. The product is sucked off and crystallized from 4-methyl-2-pentanone, yielding p-fluoro-α-(2-imidazolin-2-ylaminomethyl)benzyl alcohol; m.p. 153.4°C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US03983133 |
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| Quelldatensatz | uspto-grants-1976_09 |
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| ORD ID | ord-5e07924bcc1c4a1786b6b7b727016d36 |
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| Quellennotiz | uspto-grants-1976_09 |
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